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Antiapoptotic function of RNA-binding protein HuR effected through prothymosin α

We report the antiapoptotic effect of RNA-binding protein HuR, a critical regulator of the post-transcriptional fate of target transcripts. Among the most prominent mRNAs complexing with HuR is that encoding prothymosin α (ProTα), an inhibitor of the apoptosome. In HeLa cells, treatment with the apo...

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Detalhes bibliográficos
Main Authors: Lal, Ashish, Kawai, Tomoko, Yang, Xiaoling, Mazan-Mamczarz, Krystyna, Gorospe, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1142594/
https://ncbi.nlm.nih.gov/pubmed/15861128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600661
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