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Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase
Bloom's syndrome (BS) is an autosomal recessive human disorder characterized by genomic instability and a predisposition to a wide variety of cancers. The gene mutated in BS, BLM, encodes a protein containing three domains: an N-terminal domain whose function remains elusive, a helicase domain...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1142346/ https://ncbi.nlm.nih.gov/pubmed/15930159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki619 |
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