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Locus Control Region of the Human CD2 Gene in a Lentivirus Vector Confers Position-Independent Transgene Expression
Vectors derived from murine leukemia virus (MLV) have been used in many human gene therapy clinical trials. However, insertion of the locus control regions (LCRs) derived from the β-globin gene locus or the CD2 gene into MLV vectors frequently led to vector rearrangement. Since the human immunodefic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC114217/ https://ncbi.nlm.nih.gov/pubmed/11312334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.10.4641-4648.2001 |
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