Tissue-Specific, Tumor-Selective, Replication-Competent Adenovirus Vector for Cancer Gene Therapy

We have previously described two replication-competent adenovirus vectors, named KD1 and KD3, for potential use in cancer gene therapy. KD1 and KD3 have two small deletions in the E1A gene that restrict efficient replication of these vectors to human cancer cell lines. These vectors also have increa...

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Bibliographic Details
Main Authors: Doronin, Konstantin, Kuppuswamy, Mohan, Toth, Karoly, Tollefson, Ann E., Krajcsi, Peter, Krougliak, Valeri, Wold, William S. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114124/
https://ncbi.nlm.nih.gov/pubmed/11238857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.7.3314-3324.2001
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