DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162ΔV2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8(+) T-Cell-Depleted Rhesus Macaques

DNA immunization of macaques with the SF162ΔV2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8(+) T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had l...

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Autori principali: Cherpelis, S., Shrivastava, I., Gettie, A., Jin, X., Ho, D. D., Barnett, S. W., Stamatatos, L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC114060/
https://ncbi.nlm.nih.gov/pubmed/11152527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.3.1547-1550.2001
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