Novel Ser79Leu and Ser81Ile Substitutions in the Quinolone Resistance-Determining Regions of ParC Topoisomerase IV and GyrA DNA Gyrase Subunits from Recent Fluoroquinolone-Resistant Streptococcus pneumoniae Clinical Isolates

Resistance of Streptococcus pneumoniae to fluoroquinolones is caused predominantly by amino acid substitutions at positions Ser79 of ParC and Ser81 of GyrA to either Phe or Tyr encoded in the quinolone resistance-determining regions of the parC topoisomerase IV and gyrA DNA gyrase genes. Analysis of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Korzheva, Nataliya, Davies, Todd A., Goldschmidt, Raul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2005
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140505/
https://ncbi.nlm.nih.gov/pubmed/15917550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2479-2486.2005
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