An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse

We have developed a sensitized screen to identify genes involved in gene silencing, using random N-ethyl-N-nitrosourea mutagenesis on mice carrying a variegating GFP transgene. The dominant screen has produced six mutant lines, including both suppressors and enhancers of variegation. All are semidom...

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Bibliographic Details
Main Authors: Blewitt, Marnie E., Vickaryous, Nicola K., Hemley, Sarah J., Ashe, Alyson, Bruxner, Timothy J., Preis, Jost I., Arkell, Ruth, Whitelaw, Emma
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140414/
https://ncbi.nlm.nih.gov/pubmed/15890782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409375102
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