MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

In type 2 diabetes, the liver produces excessive amounts of glucose through the gluconeogenesis (GNG) pathway and consequently is partly responsible for the elevated glucose levels characteristic of the disease. In an effort to find safe and efficacious GNG inhibitors, we targeted the AMP binding si...

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Main Authors: Erion, Mark D., van Poelje, Paul D., Dang, Qun, Kasibhatla, Srinivas Rao, Potter, Scott C., Reddy, M. Rami, Reddy, K. Raja, Jiang, Tao, Lipscomb, William N.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2005
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1138262/
https://ncbi.nlm.nih.gov/pubmed/15911772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502983102
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