Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein.

Ins(1,4,5)P3-induced Ca2+ release from platelet membrane vesicles was blocked by apamin, a selective inhibitor of low-conductance Ca(2+)-activated K+ channels, and by tetrapentylammonium ion, and was weakly inhibited by tetraethylammonium ion. Other K(+)-channel blockers, i.e. charybdotoxin, 4-amino...

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Bibliografski detalji
Glavni autori: O'Rourke, F, Soons, K, Flaumenhauft, R, Watras, J, Baio-Larue, C, Matthews, E, Feinstein, M B
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1138220/
https://ncbi.nlm.nih.gov/pubmed/8010949
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