Contribution of a buried aspartate residue towards the catalytic efficiency and structural stability of Bacillus stearothermophilus lactate dehydrogenase.

The X-ray structure of lactate dehydrogenase (LDH) shows the side-chain carboxylate group of Asp-143 to be buried in the hydrophobic interior of the enzyme, where it makes hydrogen-bonding interactions with both the side-chain hydroxyl group of Ser-273 and the main-chain amide group of His-195. This...

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Detalhes bibliográficos
Main Authors: Nobbs, T J, Cortés, A, Gelpi, J L, Holbrook, J J, Atkinson, T, Scawen, M D, Nicholls, D J
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1138189/
https://ncbi.nlm.nih.gov/pubmed/8002955
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