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The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.
Protein kinase C (PKC), an enzyme which is believed to mediate the stimulatory effects of the PKC activator phorbol 12-myristate 13-acetate (PMA) on phospholipase D (PLD) activity, has a zinc-dependent structure required for phorbol ester binding. Accordingly, zinc or zinc chelators would be expecte...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1994
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1137987/ https://ncbi.nlm.nih.gov/pubmed/8129736 |
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