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Structure-activity relationships in the inhibition of serine beta-lactamases by phosphonic acid derivatives.

A new series of phosphonyl derivatives has been prepared and tested for inhibition of serine (classes A and C) beta-lactamases. The results were compared with those previously acquired with aryl phosphonate monoesters and with alkaline hydrolysis rates. A methyl p-nitrophenyl phosphate monoanion was...

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Autors principals: Rahil, J, Pratt, R F
Format: Artigo
Idioma:Inglês
Publicat: 1993
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137708/
https://ncbi.nlm.nih.gov/pubmed/8257429
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