Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase.

Lignende værker

• The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
  af: Cross, D A, et al.
  Udgivet: (1994)
• Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
  af: Welsh, G I, et al.
  Udgivet: (1993)
• Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.
  af: Shepherd, P R, et al.
  Udgivet: (1995)
• Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
  af: Stambolic, V, et al.
  Udgivet: (1994)
• Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.
  af: Eldar-Finkelman, H, et al.
  Udgivet: (1996)