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Role of leptin and melanocortin signaling in uremia-associated cachexia

The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R). We performed either subtotal nephrectomy (N) or sham operations in WT, leptin receptor–def...

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Detalhes bibliográficos
Main Authors: Cheung, Wai, Yu, Pin X., Little, Brian M., Cone, Roger D., Marks, Daniel L., Mak, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1136984/
https://ncbi.nlm.nih.gov/pubmed/15931394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI22521
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