Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2.

Eitemau Tebyg

• A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase.
  gan: Bailyes, E M, et al.
  Cyhoeddwyd: (1992)
• The post-translational processing of chromogranin A in the pancreatic islet: involvement of the eukaryote subtilisin PC2.
  gan: Arden, S D, et al.
  Cyhoeddwyd: (1994)
• Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2.
  gan: Scougall, K, et al.
  Cyhoeddwyd: (1998)
• Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cells.
  gan: Taylor, N A, et al.
  Cyhoeddwyd: (1997)
• Proinsulin processing in the rat insulinoma cell line INS after overexpression of the endoproteases PC2 or PC3 by recombinant adenovirus.
  gan: Irminger, J C, et al.
  Cyhoeddwyd: (1996)