Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase

HGO (homogentisate 1,2-dioxygenase; EC 1.13.11.5) catalyses the O(2)-dependent cleavage of HGA (homogentisate) to maleylacetoacetate in the catabolism of tyrosine. Anaerobic purification of heterologously expressed Fe(II)-containing human HGO yielded an enzyme preparation with a specific activity of...

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Detalhes bibliográficos
Main Authors: Veldhuizen, Edwin J. A., Vaillancourt, Frédéric H., Whiting, Cheryl J., Hsiao, Marvin M.-Y., Gingras, Geneviève, Xiao, Yufang, Tanguay, Robert M., Boukouvalas, John, Eltis, Lindsay D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134795/
https://ncbi.nlm.nih.gov/pubmed/15479158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041370
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