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Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation.
The mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase gene is expressed in a limited set of tissues in the adult rat. Methylation of the 5' flanking region of the gene in vitro leads to its transcriptional inactivation when transfected in hepatoma-derived cell lines. In liver and...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134633/ https://ncbi.nlm.nih.gov/pubmed/7694571 |
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