Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity.

Stimulation of the human T-cell line, Jurkat, by a monoclonal antibody (mAb) directed against the CD28 molecule leads to sustained increases in intracellular levels of Ca2+ ([Ca2+]i); the initial rise in Ca2+ comes from internal stores, followed by Ca2+ entry into the cells. The CD28 molecule also a...

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Bibliographic Details
Main Authors: Nunes, J, Klasen, S, Franco, M D, Lipcey, C, Mawas, C, Bagnasco, M, Olive, D
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134444/
https://ncbi.nlm.nih.gov/pubmed/8394695
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