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Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3
We have examined the role of a salt bridge between Lys(242) and Glu(246) in loop L4 of procaspase 3 and of mature caspase 3, and we show that the interactions are required for stabilizing the active site. Replacing either of the residues with an alanine residue results in a complete loss of procaspa...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1134137/ https://ncbi.nlm.nih.gov/pubmed/15312047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040693 |
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