Targeting the A site RNA of the Escherichia coli ribosomal 30 S subunit by 2′-O-methyl oligoribonucleotides: a quantitative equilibrium dialysis binding assay and differential effects of aminoglycoside antibiotics

The bacterial ribosome comprises 30 S and 50 S ribonucleoprotein subunits, contains a number of binding sites for known antibiotics and is an attractive target for selection of novel antibacterial agents. On the 30 S subunit, for example, the A site (aminoacyl site) close to the 3′-end of 16 S rRNA...

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Detaylı Bibliyografya
Asıl Yazarlar: Abelian, Arthur, Walsh, Andrew P., Lentzen, Georg, Aboul-Ela, Fareed, Gait, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Portland Press Ltd. 2004
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134060/
https://ncbi.nlm.nih.gov/pubmed/15294017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040246
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