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Relationship between isoelectric point of native and chemically modified insulin and liposomal fusion.

Native insulin causes fusion of negatively charged liposomes in the pH range from 3.0 to 5.5. In marked contrast, insulin with all three amino groups succinylated did not show fusion ability at any pH. On the other hand, insulin amidated with glycine methyl ester with all six carboxyl groups blocked...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Farías, R N, López Viñals, A E, Posse, E, Morero, R D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1989
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133574/
https://ncbi.nlm.nih.gov/pubmed/2690824
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