Purification and characterization of an anticonvulsant-induced human cytochrome P-450 catalysing cyclosporin metabolism.

A form of human hepatic microsomal cytochrome P-450 (P450hA7) with subunit Mr 50,400 has been purified from an epileptic who had been receiving long-term treatment with anticonvulsant drugs. P450hA7 metabolized the immunosuppressant drug cyclosporin A and the dihydropyridine calcium channel antagoni...

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Detalhes bibliográficos
Main Authors: Shaw, P M, Barnes, T S, Cameron, D, Engeset, J, Melvin, W T, Omar, G, Petrie, J C, Rush, W R, Snyder, C P, Whiting, P H
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133483/
https://ncbi.nlm.nih.gov/pubmed/2688634
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