Effect of phorbol ester treatment on receptor-mediated versus G-protein-activator-mediated responses in platelets. Evidence for a two-site action of phorbol ester at the level of G-protein function.

Eitemau Tebyg

• Receptor- and phorbol-ester-mediated redistribution of protein kinase C in human platelets. Evidence that aggregation promotes degradation of protein kinase C.
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  Cyhoeddwyd: (1989)
• Some effects of phorbol esters are not mediated by protein kinase C
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  Cyhoeddwyd: (1989)
• Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate.
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  Cyhoeddwyd: (1986)
• Inhibition of agonist-induced platelet aggregation, Ca2+ mobilization and granule secretion by guanosine 5'-[beta-thio]diphosphate and GDP in intact platelets. Evidence for an inhibitory mechanism unrelated to the inhibition of G-protein-GTP interaction.
  gan: Krishnamurthi, S, et al.
  Cyhoeddwyd: (1988)
• Effects of phorbol esters on alpha 1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes.
  gan: García-Sáinz, J A, et al.
  Cyhoeddwyd: (1985)