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Contribution of five amino acid residues in the glutathione-binding site to the function of human glutathione transferase P1-1.

Five amino acids in proximity to GSH bound in the active-site cavity of human Class Pi glutathione transferase (GST) P1-1 were mutated by oligonucleotide-directed site-specific mutagenesis. The following mutations gave catalytically active mutant proteins with the proper dimeric structure: Arg14----...

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Библиографические подробности
Главные авторы: Widersten, M, Kolm, R H, Björnestedt, R, Mannervik, B
Формат: Artigo
Язык:Inglês
Опубликовано: 1992
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132797/
https://ncbi.nlm.nih.gov/pubmed/1637329
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