Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.

The ion channel probe phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] selectively inhibited aggregation, secretion and ultrastructural changes in platelets induced by adrenaline, but did not affect activation induced by other common platelet agonists such as alpha-thrombin, ADP, collagen or io...

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Autores principales: Jamieson, G A, Agrawal, A K, Greco, N J, Tenner, T E, Jones, G D, Rice, K C, Jacobson, A E, White, J G, Tandon, N N
Formato: Artigo
Lenguaje:Inglês
Publicado: 1992
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132740/
https://ncbi.nlm.nih.gov/pubmed/1322125
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