Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily.

Evidence from human studies in vivo and in vitro strongly suggests that the methylhydroxylation of tolbutamide and the 4-hydroxylation of phenytoin, the major pathways in the elimination of these two drugs, are catalysed by the same cytochrome P-450 isoenzyme(s). In the present study we used site-di...

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Bibliografske podrobnosti
Main Authors: Veronese, M E, Doecke, C J, Mackenzie, P I, McManus, M E, Miners, J O, Rees, D L, Gasser, R, Meyer, U A, Birkett, D J
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132200/
https://ncbi.nlm.nih.gov/pubmed/8424795
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