Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils.

Platelet-activating factor (PAF) desensitizes as well as stimulates its various target cells, We find that human polymorphonuclear neutrophils (PMN) exposed to PAF became maximally unresponsive to a second PAF challenge within 15-90 s in assays of Ca2+ mobilization and degranulation. The cells regai...

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Bibliographic Details
Main Authors: O'Flaherty, J T, Jacobson, D P, Redman, J F
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132104/
https://ncbi.nlm.nih.gov/pubmed/1332696
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