Aluminium perturbs oscillatory phosphoinositide-mediated calcium signalling in hormone-stimulated hepatocytes.

Aluminium is known to be toxic to cells from bone, brain and bone marrow but the molecular target(s) affected by Al3+ are not known. We show here that Al3+ disrupts the oscillatory free Ca2+ responses of hepatocytes exposed to the Ca2(+)-mobilizing agonist phenylephrine. Al3+ initially increases the...

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Bibliografiske detaljer
Main Authors: Schöfl, C, Sanchez-Bueno, A, Dixon, C J, Woods, N M, Lee, J A, Cuthbertson, K S, Cobbold, P H, Birchall, J D
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131614/
https://ncbi.nlm.nih.gov/pubmed/2167073
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