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HIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell culture

A library of three synthetic ribozymes with randomized arms, targeting NUX, GUX and NXG triplets, respectively, were used to identify ribozyme-accessible sites on the HIV-1 LTR transcript comprising positions –533 to 386. Three cleavable sites were identified at positions 109, 115 and 161. Ribozymes...

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Detalhes bibliográficos
Main Authors: Bramlage, Birgit, Luzi, Ettore, Eckstein, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC113160/
https://ncbi.nlm.nih.gov/pubmed/11058100
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