Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.

1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed mutagenesis, and subcloned it into the monkey kidney (COS-7) cell expression vector, pSVL. 2. The cDNA encodes a 49 kDa protein with coumarin 7-hydroxylase (COH) activity...

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Main Authors: Miles, J S, McLaren, A W, Forrester, L M, Glancey, M J, Lang, M A, Wolf, C R
Formato: Artigo
Idioma:Inglês
Publicado: 1990
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131297/
https://ncbi.nlm.nih.gov/pubmed/2334398
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