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Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

Substantial increases in the concentrations of the excitotoxin and N-methyl-D-aspartate-receptor agonist quinolinic acid (QUIN) occur in human patients and non-human primates with inflammatory diseases. Such increases were postulated to be secondary to induction of indoleamine 2,3-dioxygenase in inf...

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Detalhes bibliográficos
Main Authors: Heyes, M P, Saito, K, Markey, S P
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130930/
https://ncbi.nlm.nih.gov/pubmed/1534219
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