Poliovirus Mutants at Histidine 195 of VP2 Do Not Cleave VP0 into VP2 and VP4

The final stage of poliovirus assembly is characterized by a cleavage of the capsid precursor protein VP0 into VP2 and VP4. This cleavage is thought to be autocatalytic and dependent on RNA encapsidation. Analysis of the poliovirus empty capsid structure has led to a mechanistic model for VP0 cleava...

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Bibliographic Details
Main Authors: Hindiyeh, Musa, Li, Qi-Han, Basavappa, Ravi, Hogle, James M., Chow, Marie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112939/
https://ncbi.nlm.nih.gov/pubmed/10516013
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