Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val

We previously showed that a didanosine-selected mutation in pNL4-3 background conferred a replication disadvantage on human immunodeficiency virus type 1, resulting in a loss of replication fitness. This work has been extended by showing that a recombinant virus with the HXBc2 backbone and reverse t...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Sharma, Prem L., Crumpacker, Clyde S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Replication
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112864/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482597/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.10.8448-8456.1999
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