Both Neutralization Resistance and High Infectivity Phenotypes Are Caused by Mutations of Interacting Residues in the Human Immunodeficiency Virus Type 1 gp41 Leucine Zipper and the gp120 Receptor- and Coreceptor-Binding Domains

Neutralization resistance of human immunodeficiency virus type 1 (HIV-1) is a major impediment to vaccine development. We have found that residues of HIV-1 MN strain in the C terminus of gp120 and the leucine zipper (LZ) region of gp41 viral envelope proteins interact cooperatively to determine neut...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Park, Eun Ju, Quinnan, Gerald V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112630/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10364321/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.7.5707-5713.1999
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