The Major Attenuating Mutations of the Respiratory Syncytial Virus Vaccine Candidate cpts530/1009 Specify Temperature-Sensitive Defects in Transcription and Replication and a Non-Temperature-Sensitive Alteration in mRNA Termination

The live-attenuated respiratory syncytial virus vaccine candidate cpts530/1009 was previously shown to contain two separate amino acid changes in the L protein, mutations 530 and 1009 (Phe-521→Leu and Met-1169→Val, respectively, according to the amino acid sequence of the L protein). Each mutation i...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Juhasz, Katalin, Murphy, Brian R., Collins, Peter L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112566/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10233984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.6.5176-5180.1999
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