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Reversion of a Human Immunodeficiency Virus Type 1 Matrix Mutation Affecting Gag Membrane Binding, Endogenous Reverse Transcriptase Activity, and Virus Infectivity

We previously characterized mutations in the human immunodeficiency virus type 1 matrix (MA) protein that displayed reduced infectivity in single-round assays, defects in the stable synthesis of viral DNA in infected cells, and impaired endogenous reverse transcriptase activity. The mutants, which c...

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Udgivet i:J Virol
Principais autores: Kiernan, Rosemary E., Ono, Akira, Freed, Eric O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112515/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10233933/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.6.4728-4737.1999
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