Human Immunodeficiency Virus-Specific Circulating CD8 T Lymphocytes Have Down-Modulated CD3ζ and CD28, Key Signaling Molecules for T-Cell Activation

Although human immunodeficiency virus (HIV)-infected subjects without AIDS have a high frequency of HIV-specific CD8 T lymphocytes, cellular immunity is unable to control infection. Freshly isolated lymphocytes often do not lyse HIV-infected targets in 4-h cytotoxicity assays. A large fraction of ci...

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Pubblicato in:	J Virol
Autori principali:	Trimble, Linda A., Shankar, Premlata, Patterson, Mark, Daily, Johanna P., Lieberman, Judy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112252/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10906185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.16.7320-7330.2000
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