Suppression of Acute Viremia by Short-Term Postexposure Prophylaxis of Simian/Human Immunodeficiency Virus SHIV-RT-Infected Monkeys with a Novel Reverse Transcriptase Inhibitor (GW420867) Allows for Development of Potent Antiviral Immune Responses Resulting in Efficient Containment of Infection

A nonnucleoside reverse transcriptase (RT) inhibitor, GW420867, was tested for postexposure prophylaxis (PEP) in rhesus macaques experimentally infected with 100 50% tissue culture infective doses of a chimeric simian/human immunodeficiency virus (SHIV) containing the RT gene of HIV-1 (SHIV-RT). Ani...

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Main Authors: Mori, Kazuyasu, Yasutomi, Yasuhiro, Sawada, Shuzo, Villinger, Francois, Sugama, Kazushige, Rosenwith, Brigitte, Heeney, Jonathan L., Überla, Klaus, Yamazaki, Shudo, Ansari, Aftab A., Rübsamen-Waigmann, Helga
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC112067/
https://ncbi.nlm.nih.gov/pubmed/10846052
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