Tumor Necrosis Factor Alpha-Deficient, but Not Interleukin-6-Deficient, Mice Resist Peripheral Infection with Scrapie

In most peripheral infections of rodents and sheep with scrapie, infectivity is found first in lymphoid tissues and later in the central nervous system (CNS). Cells within the germinal centers (GCs) of the spleen and lymph nodes are important sites of extraneural replication, from which infection is...

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Bibliographic Details
Main Authors: Mabbott, Neil A., Williams, Alun, Farquhar, Christine F., Pasparakis, Manolis, Kollias, Giorgos, Bruce, Moira E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC111835/
https://ncbi.nlm.nih.gov/pubmed/10708451
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