Sensitivity to a Nonpeptidic Compound (RPR103611) Blocking Human Immunodeficiency Virus Type 1 Env-Mediated Fusion Depends on Sequence and Accessibility of the gp41 Loop Region

The triterpene RPR103611 is an efficient inhibitor of membrane fusion mediated by the envelope proteins (Env, gp120-gp41) of CXCR4-dependent (X4) human immunodeficiency virus type 1 (HIV-1) strains, such as HIV-1(LAI) (LAI). Other X4 strains, such as HIV-1(NDK) (NDK), and CCR5-dependent (R5) HIV-1 s...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	J Virol
Prif Awduron:	Labrosse, Béatrice, Treboute, Carole, Alizon, Marc
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 2000
Pynciau:	Vaccines and Antiviral Agents
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111694/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10666243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.5.2142-2150.2000
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