Granzyme A, a Noncytolytic Component of CD8(+) Cell Granules, Restricts the Spread of Herpes Simplex Virus in the Peripheral Nervous Systems of Experimentally Infected Mice

Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that...

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Bibliografiska uppgifter
Huvudupphovsmän: Pereira, Rosemarie A., Simon, Markus M., Simmons, Anthony
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC111627/
https://ncbi.nlm.nih.gov/pubmed/10623769
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