Human Herpesvirus 8 Open Reading Frame 21 Is a Thymidine and Thymidylate Kinase of Narrow Substrate Specificity That Efficiently Phosphorylates Zidovudine but Not Ganciclovir

Human herpesvirus 8 (HHV8) open reading frame (ORF) 21 is predicted to encode a protein similar to the thymidine kinase (TK) enzyme of other herpesviruses. Expressed in mammalian cells, ORF 21 was found to have low TK activity, based on poor growth in media containing hypoxanthine-aminopterin-thymid...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Gustafson, Erik A., Schinazi, Raymond F., Fingeroth, Joyce D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10623730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.2.684-692.2000
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