Chimeric Bovine Respiratory Syncytial Virus with Glycoprotein Gene Substitutions from Human Respiratory Syncytial Virus (HRSV): Effects on Host Range and Evaluation as a Live-Attenuated HRSV Vaccine

We recently developed a system for the generation of infectious bovine respiratory syncytial virus (BRSV) from cDNA. Here, we report the recovery of fully viable chimeric recombinant BRSVs (rBRSVs) that carry human respiratory syncytial virus (HRSV) glycoproteins in place of their BRSV counterparts,...

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Autors principals: Buchholz, Ursula J., Granzow, Harald, Schuldt, Kathrin, Whitehead, Stephen S., Murphy, Brian R., Collins, Peter L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC111453/
https://ncbi.nlm.nih.gov/pubmed/10627529
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