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Endogenous Interleukin-6 Plays a Crucial Protective Role in Streptococcal Toxic Shock Syndrome via Suppression of Tumor Necrosis Factor Alpha Production

During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-α) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-α monoclonal antibody treatment decreased mortality and muscular ne...

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Detaylı Bibliyografya
Asıl Yazarlar: Diao, Hongyan, Kohanawa, Masashi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1111866/
https://ncbi.nlm.nih.gov/pubmed/15908405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.6.3745-3748.2005
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