Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia

HIF-1α is the regulated subunit of the HIF-1 transcription factor, which induces transcription of a number of genes involved in the cellular response to hypoxia. The HIF-1α protein is rapidly degraded in cells supplied with adequate oxygen but is stabilized in hypoxic cells. Using polysome profile a...

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Publié dans:	Mol Biol Cell
Auteurs principaux:	Lang, Kenneth J. D., Kappel, Andreas, Goodall, Gregory J.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Cell Biology 2002
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111144/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.02-02-0017
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