Targeted Destruction of DNA Replication Protein Cdc6 by Cell Death Pathways in Mammals and Yeast

The highly conserved Cdc6 protein is required for initiation of eukaryotic DNA replication and, in yeast and Xenopus, for the coupling of DNA replication to mitosis. Herein, we show that human Cdc6 is rapidly destroyed by a p53-independent, proteasome-, and ubiquitin-dependent pathway during early s...

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Main Authors: Blanchard, Frederic, Rusiniak, Michael E., Sharma, Karuna, Sun, Xiaolei, Todorov, Ivan, Castellano, M. Mar, Gutierrez, Crisanto, Baumann, Heinz, Burhans, William C.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111125/
https://ncbi.nlm.nih.gov/pubmed/12006651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.02-02-0010
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