Role of the RNA Polymerase α Subunits in MetR-Dependent Activation of metE and metH: Important Residues in the C-Terminal Domain and Orientation Requirements within RNA Polymerase

Many transcription factors activate by directly interacting with RNA polymerase (RNAP). The C terminus of the RNAP α subunit (αCTD) is a common target of activators. We used both random mutagenesis and alanine scanning to identify αCTD residues that are crucial for MetR-dependent activation of metE...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Fritsch, Paula S., Urbanowski, Mark L., Stauffer, George V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110999/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10986259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.19.5539-5550.2000
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