Effective Induction of Simian Immunodeficiency Virus-Specific Systemic and Mucosal Immune Responses in Primates by Vaccination with Proviral DNA Producing Intact but Noninfectious Virions

We report a pilot evaluation of a DNA vaccine producing genetically inactivated simian immunodeficiency virus (SIV) particles in primates, with a focus on eliciting mucosal immunity. Our results demonstrate that DNA vaccines can be used to stimulate strong virus-specific mucosal immune responses in...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Wang, Shainn-Wei, Kozlowski, Pamela A., Schmelz, Gretchen, Manson, Kelledy, Wyand, Michael S., Glickman, Rhona, Montefiori, David, Lifson, Jeffrey D., Johnson, R. Paul, Neutra, Marian R., Aldovini, Anna
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110926/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11044096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.22.10514-10522.2000
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