Minimising the secondary structure of DNA targets by incorporation of a modified deoxynucleoside: implications for nucleic acid analysis by hybridisation

Some regions of nucleic acid targets are not accessible to heteroduplex formation with complementary oligonucleotide probes because they are involved in secondary structure through intramolecular Watson–Crick pairing. The secondary conformation of the target may be destabilised to assist its interac...

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Опубліковано в::	Nucleic Acids Res
Автори:	Nguyen, Hong-Khanh, Southern, Edwin M.
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Oxford University Press 2000
Предмети:	Article
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.20.3904
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