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Strand invasion by mixed base PNAs and a PNA–peptide chimera

Peptide nucleic acid oligomers (PNAs) have a remarkable ability to invade duplex DNA at polypurine–polypyrimidine target sequences. Applications for PNAs in medicine and biotechnology would increase if the rules governing their hybridization to mixed base sequences were also clear. Here we describe...

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Autors principals: Zhang, Xiao, Ishihara, Tsutomu, Corey, David R.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC110698/
https://ncbi.nlm.nih.gov/pubmed/10954602
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